To minimize fracture risk, diverse and varied training of high intensity (multimodal training) is recommended to increase bone strength. However, the effectiveness of different training programmes performed in community settings remain uncertain. The present study aimed to evaluate the feasibility and the effectiveness of 19-week of multimodal training in a local community center in Copenhagen, Denmark. The health promotion initiative had special emphasis on musculoskeletal health in postmenopausal women.
A local community center was offering supervised multimodal training (MMT) to postmenopausal, healthy women twice weekly, and the aim of the present study was to evaluate the feasibility and the musculoskeletal health promoting effects of the training. The evaluation study lasted for 19 weeks, and the average attendance rate of MMT participants had to be \> 1 hour weekly. The primary outcomes were bone mineral density (BMD) assessed by Dual-Energy X-ray Absorptiometry (DXA) scanning and the fasted plasma concentration of bone turnover markers (BTM): N-terminal propeptide of type I procollagen (P1NP) , C-terminal telopeptide of type I collagen (CTX), Osteocalcin), while secondary outcomes were body composition variables, dynamic postural balance and functional muscle strength. To test within- and between-group differences in the pre and post outcomes the training group (MMT) was compared with a sedentary control group (CON). Every participant was fully informed before giving her written informed consent to the procedures and potential discomfort associated with the study. The study was conducted in accordance with the Declaration of Helsinki and approved by the local ethics committee of the Capital Region of Denmark, H-18044190.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
28
Supervised multimodal exercise training (MMT) performed 1-2 hours weekly for 19 weeks
University of Copenhagen, Department of Nutrition, Exercise and Sports
Copenhagen, Denmark
Whole-body and regional BMD
bone mineral density (g/cm2)
Time frame: 19 weeks
Osteocalcin
Concentration of Osteocalcin in plasma in fasted state (µg/l)
Time frame: 3 weeks and 19 weeks
P1NP
Concentration of P1NP in plasma in fasted state (µg/l)
Time frame: 3 weeks and 19 weeks
CTX
Concentration of CTX in plasma in fasted state (ng/l)
Time frame: 3 weeks and 19 weeks
Body fat percentage
Body fat percentage (%)
Time frame: 19 weeks
Visceral adipose tissue (VAT)
Volume (m3)
Time frame: 19 weeks
Body weight
kg
Time frame: 19 weeks
BMI
kg/m2
Time frame: 19 weeks
Total fat mass
kg
Time frame: 19 weeks
Total lean body mass (LBM)
kg
Time frame: 19 weeks
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Whole-body bone mineral content (BMC)
g
Time frame: 19 weeks
dynamic balance
time to fulfill a four-square-balance test (sec)
Time frame: 19 weeks
dynamic muscle strength
Jump-and-reach-test (cm)
Time frame: 19 weeks