Allograft patients have a complex care pathway and are left with a large number of prescribed medications. They have to deal with changes linked to the transplant (change in taste, fatigue, regular monitoring, risk of GVH (graft versus host) complications, infectious risks, change in eating habits, etc.), and a large number of associated drugs (immunosuppressants, anti-infectious prophylaxis and supplements (folic acid, magnesium, bile salts, etc.), which are added to any pre-existing chronic pathologies. Therapeutic adherence of these patients is a real challenge. Indeed, the success of the transplant and the complications that may arise (graft rejection, GVH, infections, death, hospitalisation, etc.) are closely linked to good or poor therapeutic adherence. Moreover, the majority of these patients are young and are not used to taking many treatments, which will change after the transplant. Adherence to treatment consists of three phases: * Acceptance of the disease and the benefits of treatment, * Compliance: following the instructions of the prescription (dosage and schedule), * Persistence: consistency of compliance over time. Support from the care team throughout the management of these patients is necessary for good therapeutic adherence in order to prevent and act early on the difficulties encountered (appearance of side effects linked to the treatments, large number of tablets per day, duration of treatment (1 to 2 years), risk of GVH, significant asthenia and difficulty in concentrating, etc.) We have a large amount of data on therapeutic adherence and potential non-adherence factors in patients with chronic diseases (diabetes, asthma, cancer, etc.) or in solid organ transplant patients. On the other hand, there is little data on allograft patients. Most often, a parallel is made between the data present in kidney transplant patients and allograft patients. However, it is necessary to study more specifically the therapeutic adherence in this population. A recent multicentre cross-sectional study in France on adherence in allograft patients showed that 80% of adult and paediatric patients were not adherent.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
20
Pharmaceutical follow-up over 1 year and pharmaceutical interviews during the various medical consultation appointments. In addition to the usual care: * Delivery of questionnaire at the time defined in the protocol. The questionnaires will be given during the waiting time of the patients at the University Hospital of Limoges. * Extension of the duration of the usual interview by 10 minutes in order to collect the desired information.
Limoges University Hospital
Limoges, France
RECRUITINGMedication adherence level
Patient's level of medication adherence will be assessed by the 8-item Morisky test (score 0 to 13 : a score greater than or equal to 11 show good adherence)
Time frame: month 12
Factors associated with a change
Semi-structured interview conducted at M+12 post-transplant.
Time frame: month 12
Medication adherence level
Patient's level of medication adherence will be assessed by the 8-item Morisky test (score 0 to 13 : a score greater than or equal to 11 show good adherence)
Time frame: day 15
Factors associated with a change
Semi-structured interview conducted at D+15 after discharge from hospital.
Time frame: day 15
Medication adherence level
Patient's level of medication adherence will be assessed by the 8-item Morisky test (score 0 to 13 : a score greater than or equal to 11 show good adherence)
Time frame: month 3
Factors associated with a change
Semi-structured interview conducted at M+3 post-transplant.
Time frame: month 3
Medication adherence level
Patient's level of medication adherence will be assessed by the 8-item Morisky test (score 0 to 13 : a score greater than or equal to 11 show good adherence)
Time frame: month 6
Factors associated with a change
Semi-structured interview conducted at M+6 post-transplant.
Time frame: month 6
Medication adherence level
Patient's level of medication adherence will be assessed by the 8-item Morisky test (score 0 to 13 : a score greater than or equal to 11 show good adherence)
Time frame: month 9
Factors associated with a change
Semi-structured interview conducted at M+9 post-transplant.
Time frame: month 9
Patient's representations of their medication after transplantation
Use of the "belief about medicines" questionnaire : 18 items. Each item is rated from 0 to 5 (0 = strongly disagree, 5 = strongly agree)
Time frame: day 15
Patient's representations of their medication after transplantation
semi-directive interview approach using specific items
Time frame: day 15
Patient's representations of their medication after transplantation
Use of the "belief about medicines" questionnaire : 18 items. Each item is rated from 0 to 5 (0 = strongly disagree, 5 = strongly agree)
Time frame: month 6
Patient's representations of their medication after transplantation
semi-directive interview approach using specific items
Time frame: month 6
Patient's representations of their medication after transplantation
Use of the "belief about medicines" questionnaire : 18 items. Each item is rated from 0 to 5 (0 = strongly disagree, 5 = strongly agree)
Time frame: month 12
Patient's representations of their medication after transplantation
semi-directive interview approach using specific items
Time frame: month 12
Representation of the information given on transplant drugs according to the health professionals accompanying the transplant patient
ad hoc closed-ended questionnaire conducted prior to transplantation
Time frame: day 0
Representation of the information given on transplant drugs according to the health professionals accompanying the transplant patient
ad hoc closed-ended questionnaire
Time frame: month 3
Representation of the information given on transplant drugs according to the health professionals accompanying the transplant patient
ad hoc closed-ended questionnaire
Time frame: month 6
Representation of the information given on transplant drugs according to the health professionals accompanying the transplant patient
ad hoc closed-ended questionnaire
Time frame: month 12
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