The Significance of Sodium Balance and the Value of Salt-blood Test in Identifying Salt Sensitive Patients

Regional Hospital Holstebro72 enrolled

Overview

This is a randomized controlled trial with 72 patients with hypertension examining the effects on blood pressure of sodium restriction and whether the blood analysis Salt-blood test is associated to a decrease in blood pressure. Patients will be randomized 2:1 to either sodium restriction or usual diet for 4 weeks. Baseline measures will be done before intervention and outcome measures after the 4 weeks.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hypertension,Essential

Interventions

Sodium restrictionBEHAVIORAL

Participants will be guided in minimizing sodium intake. Guidance will be both oral and written. Bread with low sodium content will be offered to the participants.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * BMI ≤ 35 kg/m2 * Essential hypertension * eGFR \> 15 ml/min/1,73m2 * Albumine-to-creatinine-ratio \< 500 mg/g * Safe anticonception if women in childbearing age. * Able to adhere to dietary regimen Exclusion Criteria: * Secondary hypertension * Clinically significant heart failure (NYHA 3-4) * Clinically significant liver disease * Diabetes mellitus (type 1 and 2) * Active cancer (except skin cancer) * Renal transplant * Recent stroke, transcient ischemic attack or myocardial infarction (within 6 months) * Proliferative glomerulonephritis or ANCA-related disease * Continuous immunosuppressant treatment * Pregnancy or lactation * Alcohol abuse * If the investigator finds the participant unfit to complete the project

Locations (1)

University Clinic in Nephrology and Hypertension

Herning, Denmark

Outcomes

Primary Outcomes

Change in systolic 24-hour blood pressure

Difference in systolic blood pressure measured before and after intervention

Time frame: Measured before and after 4 weeks' intervention

Data from ClinicalTrials.gov

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