The purpose of this study is to determine whether a consultation with a Personalized Therapeutics Clinic, or PTC, will help participants lower the risk for side effects (drug-drug interactions and drug-gene interactions) when taking many medications and help providers improve prescribing decisions for participants. A PTC is a clinical that will test your genes to gather information about your health that may help guide prescribing advice and offer you new information about your prescriptions. Doctors leading this study will look for variations (differences) in your genes that may suggest that you are at greater risk of having side effects or a greater chance of benefiting from certain medications. Individuals in this study will participate for roughly 9 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
1,300
A profile based on genetic testing that shows information about how the participant's medications they are taking interact with each other.
A profile based on genetic testing that shows information about how the participant's genes interact with/respond to certain medications they are taking.
The standard treatment and prescribing for the participant's specific type of cancer.
University of Chicago Medicine
Chicago, Illinois, United States
RECRUITINGChange in Rate of Drug-Drug Interactions and Drug-Gene Interactions Among Participants
The change in the composite rate of drug-drug interactions (DDIs) and drug-gene interactions (DGIs) from baseline (at beginning of study) and after each intervention compared between all three arms.
Time frame: 9 months
Participants At High-Risk for Drug-Drug and Drug-Gene Interactions
Reported as a percentage of total hospitalized participants
Time frame: 9 months
Strategy to Implement at Personalize Therapeutic Clinic (PTC) at Specific Sites Based on Available Mediators (PTC Partners)
An implementation strategy for a site-specific Personalized Therapeutic Clinic (PTC) as assessed by evaluating which mediators and moderators who may be able to adopt PTC recommendations.
Time frame: 9 months
Rate of Hospitalizations
The rate of hospitalizations among participants in all three arms as assessed by study notes/clinical record.
Time frame: 9 months
Rate of Emergency Department Visits
Rate of emergency department visits among participants in all three arms as assessed by study notes/clinical record.
Time frame: 9 months
Rate of Reported Adverse Events as Assessed by Clinical Records
Rate of reported adverse drug events among participants in all three arms as assessed by study notes/clinical record.
Time frame: 9 months
Changes in Participant Knowledge and Perceptions of the Personalized Therapeutic Clinic (PTC) as Assessed by Survey Results
Changes in participant knowledge and perceptions of the PTC will be assessed using surveys administered at baseline and after the first post-PTC visit with their primary treating provider.
Time frame: 9 months
Changes in provider knowledge and perceptions of the Personalized Therapeutic Clinics (PTC) Assessed by Survey Results
Changes in provider knowledge and perceptions of the PTC as assessed by survey collected from providers at baseline and at the end of study.
Time frame: 9 months
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