Effect of Bariatric Surgery on Cardiac Function in Patients With Hypertension

Beijing Friendship Hospital40 enrolled

Overview

The purpose of this study is to investigate the effect of bariatric surgery on cardiac function assessed by echocardiography in patients with hypertension.

Obesity is the most common chronic metabolic disease worldwide, causing the increasing burden of cardiovascular risk factors such as hypertension, and affecting cardiac structure and function in the long term. Nowadays, bariatric surgery is regarded as the most effective approach for weight loss, and the only approach for reducing obesity-related cardiovascular events. However, the effect of different bariatric surgeries such as laparoscopic sleeve gastrectomy (LSG) or Roux-en-Y gastric bypass (RYGB) on cardiac function in patients with hypertension is still unclear. Therefore, the aim of this study was to evaluate the benefit of different bariatric surgeries on cardiac structure and function echocardiography in patients with hypertension.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Bariatric Surgery Hypertension

Interventions

LSGPROCEDURE

Laparoscopic sleeve gastrectomy (LSG) together with medical treatment aiming the control of cardiovascular risks including hypertension, diabetes mellitus or dyslipidemia.

RYGBPROCEDURE

Roux-en-Y gastric bypass (LRYGB) together with medical treatment aiming the control of cardiovascular risks including hypertension, diabetes mellitus or dyslipidemia.

Eligibility

Sex: ALLMin age: 17 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18-70 years old * BMI\>24kg/m2 * Bariatric surgery patients of Beijing Friendship Hospital * History of hypertension and treated with ≥2 antihypertensive drugs for more than 4 weeks * No major barriers to provide written consent Exclusion Criteria: * Secondary hypertension, except because of sleep apnea * cardiovascular disease (myocardial infarction, heart failure, stroke or coronary revascularization) within 6 months * Severe concomitant diseases (autoimmune disease, malignancy, late stage of liver diseases, respiratory diseases and digestive diseases) * Unable to understand or comply with the study procedures

Locations (1)

Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Changes on left ventricular ejection fraction (LVEF)

Changes on LVEF in % assessed with the use of transthoracic echocardiography (TTE).

Time frame: 12 months

Secondary Outcomes

Changes on left ventricular ejection fraction (LVEF)

Changes on LVEF in % assessed with the use of TTE.

Time frame: 24 months

Changes on left ventricular end-diastolic diameter (LVEDD)

Changes on LVEDD in mm assessed with the use of TTE.

Time frame: 12 months

Changes on left ventricular end-diastolic diameter (LVEDD)

Changes on LVEDD in mm assessed with the use of TTE.

Time frame: 24 months

Major adverse cardiac events

including all-cause mortality, cardiac death, acute myocardial infarction, stroke, heart failure, ventricular tachycardia or ventricular fibrillation requiring shock delivery.

Time frame: 12 months

Major adverse cardiac events

including all-cause mortality, cardiac death, acute myocardial infarction, stroke, heart failure, ventricular tachycardia or ventricular fibrillation requiring shock delivery.

Time frame: 24 months

Changes on number of antihypertensive drugs

Changes on of the total number of antihypertensive medications while maintaining office systolic and diastolic blood pressure \<140 mm Hg and 90 mm Hg, respectively.

Time frame: 12 months

Central Contacts

Rongchong Huang, M.D.

CONTACT

+86-13811039417 rchuang@ccmu.edu.cn

Data from ClinicalTrials.gov

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