The objective of our study is to compare in vitro fertilization (IVF) outcomes between fresh embryo transfer (ET) and frozen-thawed ET in women with polycystic ovary syndrome (PCOS).
Eligible women will be randomized to two groups in a ratio of 1:1 . Both the patients and the clinicians will be aware of the allocated arm. The patients (110) will be equally randomized into two groups: Group A will undergo a day 3 fresh embryo transfer after ovarian stimulation, luteal phase support will be started just after follicular aspiration. Group B will have all of their embryo cryopreserved after ovarian stimulation with no luteal phase support after the aspiration and then undergo a frozen-thawed day 3 embryo transfer. Controlled ovarian stimulation will be done using the gonadotropin releasing hormone (GnRH) antagonist protocol then human chorionic gonadotropin( HCG) 5000 IU trigger for final oocyte maturation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
110
55 patients undergoing fresh embryo transfer after ovarian stimulation followed by luteal phase support
55 patients undergoing frozen embryo transfer after ovarian stimulation followed by cryopreservation of all embryos and transfer in another cycle.
Marwa Eid
Cairo, Egypt
RECRUITINGClinical pregnancy rate
Transvaginal Ultrasound to detect gestational sac(GS)
Time frame: 35 days after embryo transfer
Chemical pregnancy rate
Serum β-human chorionic gonadotropin (HCG) will be measured to determine pregnancy after embryo transfer.
Time frame: 14 days after embryo transfer.
Early ovarian hyperstimulation syndrome rate(OHSS rate)
Abdominal ultrasound ,Hematocrit
Time frame: 3 days after follicular aspiration
Ectopic pregnancy rate
BHCG then doubling after 48 hours ,vaginal ultrasound
Time frame: 14 days for BHCG , vaginal US 3 weeks after transfer
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