To investigate the safety and efficacy of preoperative IMRT and concurrent Anlotinib Hydrochloride for primary truncal or extremity soft tissue sarcoma; To investigate the Quality of life and extremity function post-combination treatment; To study the mechanism of radio-sensitizing effects of Anlotinib Hydrochloride for primary truncal or extremity soft tissue sarcoma; To assess the relationship between the MRI imaging, pathological findings and local control.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Anlotinib 12mgQD, from D1 of pre-operative IMRT to 1 month after end of IMRT
Radiotherapy Department of Cancer Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
RECRUITINGMajor wound complications
Time frame: 4-months post-surgery
Acute and late toxicities
Number of participants with treatment-related adverse events as assessed by CTCAE v5.0
Time frame: acute toxicities were evaluated during and 3 months after IMRT, late toxicities were evaluted after 6 months
Quality of Life
Evaluate quality of life by QOL questionnaires at different time points
Time frame: pre-IMRT, end of IMRT, 1 months post-IMRT, and every 3 to 6 months during follow-up
Extremity function
Evaluate quality of life by MSTS forms at different time points
Time frame: pre-IMRT, end of IMRT, 1 months post-IMRT, and every 3 to 6 months during follow-up
Pathological remission rate
evaluate the tumor remission rate microscopically
Time frame: 2 weeks after operation
Local control
Time frame: 2-year
Overall Survival
Time frame: 2-year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.