The primary objects of this study is to explore the potential effect of the autologous patch to optimize wound healing after skin cancer surgery with Mohs micrographic surgery (MMS) in the face in a randomized controlled trial comparing autologous patch healing versus secondary intention healing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
26
A patch of consisting of platelets, leucocytes and fibrin, formed by the patients own blood sample.
Mohs micrographic surgery (standard of care) (wounds will heal by secondary intention healing)
Bispebjerg Hospital
Copenhagen, Denmark
RECRUITINGBlinded assesment of wound healing at day 18-20.
Two indenpendent trained clinical doctors will evaluate clinical photos. Wounds will be evaluated fully epithelialized yes/no.
Time frame: Day 18-20
Blinded assesment of wound healing at day 11-13
Clinical photos from day 11-13 will be evaluated. Wounds will be evaluated 50% fully epithelialized yes/no.
Time frame: day 11-13
TEWL measurement
Trans epidermal water loss (TEWL) will be meassured at day 11-13 and day 18-20. The TEWL will be meassured on the wound healing site and the contralateral site of the patient's face as a control.
Time frame: day 11-13 and day 18-20
Scar evaluation using the patient-observer-scar-assesment-scale (POSAS) at 6 months follow-up.
The POSAS observer scores scar components with regards to: Vascularity, pigmentation, thickness, surface area, relief and pliability. The collected sum of scores will range from minimum 6 points to maximum 60 points.
Time frame: 6 months
Difference in microbiology between intervention wounds and control wounds.
Swab test for microbiome analysis will be conducted at day 1 and day 11-13.
Time frame: day 1 and day 11-13
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