The Multidisciplinary Expert System for the Assessment \& Management of Complex Brain Disorders (MES-CoBraD) is an interdisciplinary project combining Real-World Data (RWD) from multiple clinical and consumer sources through comprehensive, cost-efficient, and fast protocols towards improving diagnostic accuracy and therapeutic outcomes in people with Complex Brain Disorders (CoBraD), as reflected in Neurocognitive (Dementia), Sleep, and Seizure (Epilepsy) disorders and their interdependence. It brings together internationally recognized experts in medicine, engineering, computer science, social health science, law, and marketing and communication from across Europe, and combines clinical information and scientific research in CoBraD with technical innovation in secure data-sharing platforms, artificial intelligence algorithms, and expert systems of precision and personalized care, with a primary focus on improving the quality of life of patients, their caregivers, and the society at large. It leverages RWD from diverse CoBraD populations across cultural, socioeconomic, educational, and health system backgrounds, with special attention on including vulnerable populations and minorities in an equitable manner and engaging key stakeholders to maximize project impact.
Study Type
OBSERVATIONAL
Enrollment
635
concurrent overnight sleep study with full electroencephalography (in-lab or at home)
blood or CSF collection for analyses of neurodegenerative, inflammatory, and, per condition, genetic information
paper and pencil, as well as tablet based cognitive testing
week long actigraphy assessment with concurrent sleep diary acquisition
standard clinical assessment by an expert clinician in the respective field of brain disorders
Neurological Institute of Athens
Athens, Greece
Rabin Medical Center
Petah Tikva, Israel
Sant Pau Memory Clinic
Barcelona, Spain
King's College London
London, United Kingdom
Expert System Accuracy for the Assessment of Complex Brain Disorders
Pursuing external cross-validation using training and test sample data acquired during MES-CoBraD, examine the sensitivity, specificity, accuracy, and likelihood ratios in making an accurate diagnosis of Complex Brain Disorders (neurocognitive, epilepsy, sleep disorders), compared to gold standard diagnostic criteria.
Time frame: 3 years
Expert System Accuracy for the Management of Complex Brain Disorders
Pursuing external cross-validation using training and test sample data acquired during MES-CoBraD, examine the sensitivity, specificity, accuracy, and likelihood ratios in recommending standard of care treatment decisions in Complex Brain Disorders (neurocognitive, epilepsy, sleep disorders), compared to gold standard professional society recommendations.
Time frame: 3 years
Examine safety of approved therapies for Complex Brain Disorders
Test for statistically significant Side-Effect differences within 6 months of initiating approved treatments for Complex Brain Disorders between participants receiving and not receiving disease-specific therapies. Side effect reporting will be combined from patient, caregiver, and clinician input. Side effects are defined by a combination of predefined common and significant side-effect options and free text.
Time frame: 3 years
Prevalence co-occurrence of Complex Brain Disorders (Neurocognitive, Sleep, and Epilepsy disorders)
Within each of the three types of CoBraD, examine the frequency of comorbidity of the other two following comprehensive diagnostic protocols
Time frame: 3 years
Examine efficacy of approved therapies for Complex Brain Disorders
Test for statistically significant efficacy differences of using approved treatments for Complex Brain Disorders over the 3 year period of the study, between participants receiving and not receiving disease-specific therapies post sample stratification. Efficacy data will be combined from patient, caregiver, and clinician input according to the respective CoBraD efficacy outcome measures (e.g., MoCA for neurocognitive, seizure frequency and severity for epilepsy, PSQI for sleep disorders).
Time frame: 3 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.