Use of a Biological Lens of Amniotic Membrane (LV-Visio-AMTRIX) in the Treatment of Trophic Ulcers

Inclusion Criteria: * Male or female between 18 and 80 years old * Stage 2 (persistent epithelial lesion : LEP) or stage 3 (corneal ulcer) trophic ulcer affecting only one eye. Patient whose contralateral eye is affected by stage 1 neurotrophic keratitis may also be included * Two or more weeks old LEP or corneal ulcer refractory to one or more conventional nonsurgical therapies * Absence of objective evidence of improvement of the epithelial ulceration or corneal ulcer within 2 weeks prior to study inclusion * Failure of amniotic membrane treatment of the trophic ulcer: failure by absence of healing a few day after overlay treatment or 15 days after inlay grafting * Patient able to understand French language * Informed and consenting patient * Patient affiliated to a social security system or beneficiary of such a system Exclusion Criteria: * Pregnant or breastfeeding patient or without contraception for non-menopausal women * Active infectious ulcer * Preperforating ulcer or ulcer that has reached the posterior 1/3 of the storm * Allergy to Oxybuprocaine or Tetracaine eye drops, to ester type local anesthetics and to fluorescein * Current contact lens wear, including scleral lenses * NSAID eye drops and any drops containing preservatives * Antibiotic, anti-viral, anti-parasitic eye drops * Patients with identified causes of the ulcer for which medical treatment without preservatives or other healing treatment is beneficial * Ocular surgery for other pathology than the trophic ulcer in the 3 months preceding the inclusion in the study * Ophthalmologic pathology requiring daily eye drops * Monophtalmic patients * Persons deprived of liberty by a judicial or administrative decision * Adults who are subject to a legal protection measure or who are unable to express their consent