Cystic fibrosis (CF) is a genetic disease characterized by abnormal chloride transport in epithelial tissues. Inflammation is a key component contributing to the main alterations induced by the disease. The increase in life expectancy comes with a higher prevalence of CF-related comorbidities, but also with new emerging complications directly related to aging. Physical fitness and exercise practice have been previously associated to survival and better quality of life in patients with cystic fibrosis. Thus, the aim of this study is to assess the effects of a remotely supervised resistance exercise program on lung function, muscle strength, body composition, quality of life and inflammatory markers in adult patients with cystic fibrosis.
This study aims to assess the effects of a remotely supervised resistance exercise program on lung function, muscle strength, body composition, quality of life and inflammatory markers in adult patients with cystic fibrosis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
32
Eight-week program of a remotely supervised resistance exercise. Frequency: three times per week. Duration: 60 minutes per session. Training program: warm-up and joint mobility; strength exercises for different muscle groups; and cool down (stretching and breathing exercises).
Hospital La Princesa
Madrid, Spain
Change in peripheral muscle strength. Upper and lower limb muscle strength will be evaluated using the 5 maximum repetition test in specific strength machines. Handgrip strength will be measured with a dynamometer.
Change from baseline to 8 weeks
Time frame: Baseline and 8 weeks
Change in body composition (muscle mass and skeletal mass index - kg/m2) measured through dual-energy x-ray absorptiometry (DEXA)
Change from baseline to 8 weeks
Time frame: Baseline and 8 weeks
Change in plasmatic levels of Klotho
Change from baseline to 8 weeks
Time frame: Baseline and 8 weeks
Change in plasmatic levels of interleukins (IL-8 and IL-10)
Change from baseline to 8 weeks
Time frame: Baseline and 8 weeks
Change in Pulmonary Function (Lung Function)
Change from baseline to 8 weeks
Time frame: Baseline and 8 weeks
Change in quality of life evaluated using the Cystic Fibrosis Questionnaire (CFQ-R +14). Scores range from 0 to 100 with higher scores corresponding to better quality of life.
Change from baseline to 8 weeks
Time frame: Baseline and 8 weeks
Change in inspiratory muscle strength (MIP)
Change from baseline to 8 weeks
Time frame: Baseline and 8 weeks
Change in functional capacity (30 seconds sit-to-stand test)
Change from baseline to 8 weeks
Time frame: Baseline and 8 weeks
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