Dreams are a remarkable experiment in psychology and neuroscience, conducted every night in every sleeping person. 74% of awakenings from REM sleep resulted in recall of a dream, as compared with only 9% of awakenings from NREM sleep. The association between dreaming and REM sleep was subsequently replicated by many other investigators; typically, around 80% of REM awakenings yield dreams. It became clear over time that there is a good deal of mental activity that occurs during NREM sleep. Typically, it is more thought like, fragmentary, and related to daily concerns than the vivid, hallucinatory, predominantly visual narratives that are most commonly reported from REM sleep. But even this distinction appears not to be absolute. There is now wide acceptance of the view that some dreaming that is indistinguishable from REM sleep dreaming occurs in NREM sleep, most frequently in the sleep-onset period. General anesthesia causes a drug-induced state of unconsciousness and is a non-physiological process that is similar to natural sleep. Patients receiving propofol for maintenance of general anesthesia often report higher incidences of dreaming than patients maintained with volatile anesthetics. One explanation is that propofol and volatile anesthetic have different pharmacological effects in the central nervous system. An alternative explanation is that propofol is associated with more rapid emergence from anesthesia than the older volatile anesthetics, allowing patients to report their dreams before they are forgotten. In order to further verify the hypothesis, the investigators choose gynecological general anesthesia to observe whether the generation of dreams is related to the dose of general anesthesia maintenance .
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
300
The low maintenance dose propofol group was maintained at 4-6 mg/kg/h ；and The high maintenance dose propofol group was maintained at 8-12 mg/kg/h
Shengjing Hospital
Shenyang, Liaoning, China
Mean blood pressure (systolic and diastolic)
record mean blood pressure during the surgery
Time frame: 5 minutes after entering the operation room
Mean blood pressure (systolic and diastolic)
record mean blood pressure during the surgery
Time frame: Anesthesia induction to fall asleep
Mean blood pressure (systolic and diastolic)
record mean blood pressure during the surgery
Time frame: at the end of surgery
Mean blood pressure (systolic and diastolic)
record mean blood pressure during the surgery
Time frame: Upon awakening from anesthesia
Mean blood pressure (systolic and diastolic)
record mean blood pressure during the surgery
Time frame: leaving the operation room
heart rate
record heart rate during the surgery
Time frame: entering the operation room
heart rate
record heart rate during the surgery
Time frame: Anesthesia induction to fall asleep
heart rate
record heart rate during the surgery
Time frame: at the end of surgery
heart rate
record heart rate during the surgery
Time frame: Upon awakening from anesthesia
heart rate
record heart rate during the surgery
Time frame: leaving the operation room
BIS
record BIS during the surgery
Time frame: entering the operation room
BIS
record BIS during the surgery
Time frame: Anesthesia induction to fall asleep
BIS
record BIS during the surgery
Time frame: at the end of surgery
BIS
record BIS during the surgery
Time frame: Upon awakening from anesthesia
BIS
record BIS during the surgery
Time frame: leaving the operation room
Total dose of propofol
record total dose of propofol
Time frame: at the end of surgery
Dream
Dreaming during anesthesia was defined as any experience that was described by the patient as dreaming and was thought by the patient to have occurred between the induction of anesthesia and the first moment of consciousness after anesthesia.27 Awareness was defined as postoperative recall of intraoperative events. All patients who reported dreaming were considered to be "dreamers" for the purpose of the analyses, whether or not they could remember the narrative of the dream. However, only dreaming reports where the narrative was remembered were classified using five-point Likert scales as follows. Emotional content (1 very negative; 5 very positive) ● Memorability (1 can't remember narrative of dream; 5 most memorable ever) ● Visual vividness (1 not at all vivid; 5 most vivid ever) ● Amount of sound (1 no sound; 5 most sound ever)
Time frame: at the end of surgery
Postoperative adverse effects
record postoperative adverse effects
Time frame: 24 hours after surgery
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