This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.
This is a prospective pilot study to evaluate changes before and 4 weeks(+/- 1 week) after beta-blocker withdrawal in 30 HFpEF patients. The study involves 2 visits that are 4 weeks apart. The first study visit will occur at a standard of care clinic visit and the second visit will be a research visit to fill out questionnaires and perform the limited echocardiogram. No long term follow up beyond the 2nd visit.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
beta blocker discontinuation
UConn Health / John Dempsey Hospital
Farmington, Connecticut, United States
RECRUITINGChanges in KCCQ-23 score
Kansa city cardiomyopathy questionnaire (KCCQ-23)- self-administered, 23-item. questionnaire that quantifies physical limitations, symptoms, self-efficacy, social interference and quality of life. Scores are transformed to a range of 0-100, where higher scores reflect better health status.
Time frame: Baseline and after 4 weeks of beta blocker discontinuation
Changes in cardiac mechanics by echocardiography
Echocardiographic E/e' ratio
Time frame: Baseline and after 4 weeks of beta blocker discontinuation
Changes in biomarker
changes from baseline in BNP level (pg/mL) after 4 weeks of beta blocker discontinuation
Time frame: Baseline and after 4 weeks of beta blocker discontinuation
6 minute walk test
The distance (meters) covered over a time of 6 minutes. A greater distance indicates a better exercise capacity.
Time frame: Baseline and after 4 weeks of beta blocker discontinuation
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