The Healthy Human Global Project-Hong Kong aims to elucidate the heritable and non-heritable factors that drive immunological variance within a healthy population in Hong Kong. By gaining a deeper understanding of these parameters, a path can be paved for personalised and precision medicine, tailored for an Asian population.
The Healthy Human Global Project-Hong Kong (HHGP-Hong Kong) is built upon the Milieu Intérieur Consortium, a population-based study coordinated by the Institut Pasteur in Paris since 2011 (ClinicalTrials.gov study numbers NCT01699893 and NCT03905993). The Milieu Intérieur comprised of 1,000 healthy participants that are unrelated, and of Western European ancestry, to investigate inter-individual immunological variances by integrating intrinsic, environmental and genetic factors in innate immunity and adaptive immunity. Through the quantification of white blood cells by utilising standardised flow cytometry and correlating with sociodemographic variables, the Institut Pasteur team found that smoking, age, sex, and latent infection with cytomegalovirus, were the main non-genetic factors that affected variation in parameters of human immune cells. The HHGP-Hong Kong will, therefore, replicate and adapt from the study design of Milieu Intérieur recruiting 1,000 healthy participants, drawn from the FAMILY Cohort, to better understand the immunological variance within the Hong Kong population. This Cohort was part of a prospective population-based study in 2007, consisting of 46,001 participants in Hong Kong. It was the first large-scale programme to understand the determinants of physical, mental, and social wellbeing in Hong Kong. A technological platform will be developed to provide a personalized patient management strategy that takes into account individual genetics, previous infection history, resident microbiota, as well as personal lifestyle and environmental factors to define immune health.
Study Type
OBSERVATIONAL
Enrollment
1,026
No intervention
HKU Centre for Immunology & Infection Research Clinic
Hong Kong, China
Factors underlying immunological variance within the general healthy population
To identify factors (genetic, immunology and environmental) that contributes to the observed heterogeneity in immune responses (individual and population levels)
Time frame: Through study completion, an average of 1 year
Naturally occurring variability of human response
To characterise the naturally occurring variability of human response using whole genome sequencing and single nucleotide polymorphisms (SNPs) haplotyping
Time frame: Through study completion, an average of 1 year
Stimulated cytokine/chemokine measurement
To determine and measure cytokine/chemokine stimulated by 16 pattern-recognition receptors agonists (PRR agonists) or immune stimulators
Time frame: Through study completion, an average of 1 year
Characterisation of commensal airway and gut microbiota
To characterise commensal microbiota (nasopharyngeal swab and stool samples) in the study population
Time frame: Through study completion, an average of 1 year
Metagenomic architecture of faecal and nasal samples
To evaluate the metagenomic architecture of the population based on sequence analysis of bacterial, fungal and viral populations in faecal and nasal samples
Time frame: Through study completion, an average of 1 year
Immune response and nutrition association
To associate immune response with nutrition data
Time frame: Through study completion, an average of 1 year
Immune phenotype variance association with genetic polymorphisms and enterotype
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To associate immune phenotype variance with genetic polymorphisms and enterotype
Time frame: Through study completion, an average of 1 year
Heart rate variability with clinical and epidemiological data association
To associate heart rate variability with clinical and epidemiological data
Time frame: Through study completion, an average of 1 year
Inflammation with physical and mental health outcome association
To associate inflammation with physical and mental health outcomes
Time frame: Through study completion, an average of 1 year
Genotype-to-phenotype associations at a mechanistic level
To determine genotype-to-phenotype associations at a mechanistic level
Time frame: Through study completion, an average of 1 year
Retrospective and prospective clinical and epidemiological data correlation with FAMILY Cohort
To correlate retrospective and prospective clinical data with and epidemiological data from the FAMILY Cohort
Time frame: Through study completion, an average of 1 year
Immune variation comparison between healthy European (Milieu Intérieur) and Asian (HHGP- Hong Kong) populations
To compare immune variation between healthy European (Milieu Intérieur) and Asian (HHGP- Hong Kong) populations
Time frame: Through study completion, an average of 1 year