This study will evaluate the effectiveness of a 2-month time-restricted feeding (TRF) intervention in children and adolescents with obesity. The investigators will determine whether the potential beneficial effects of the intervention in this population are maintained over time. Furthermore, potential mechanisms mediating TRF effects will be explored, specifically focusing on the potential role of the gut microbiome and the circadian rhythm.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
67
Lifestyle intervention (usual treatment for patients with obesity). The behavioral intervention will last for 2 months.
Food intake restricted to 8 hours per day during the window between 10h and 22h. Time restricted feeding will take place 6 days per week, with the seventh day unrestricted. The intervention will last for 2 months.
Hospital Sant Joan de Deu
Barcelona, Barcelona, Spain
Change in BMI z score
Weight and height will be combined to calculate BMI. The World Health Organization growth charts will be used to calculate BMI z scores.
Time frame: Baseline, 2 months
Change in BMI z score (follow-up)
Weight and height will be combined to calculate BMI. The World Health Organization growth charts will be used to calculate BMI z scores.
Time frame: 1 year, 2 year
Change in Adiposity
Adiposity will be measured by bioimpedance
Time frame: Baseline, 2 months, 1 year, 2 year
Change in glucose metabolism
Fasting blood test will performed at each time point to analyze glucose metabolism, including glucose, HbA1c, and insulin levels.
Time frame: Baseline, 2 months, 1 year, 2 year
Change in lipid profile
Fasting blood test will performed at each time point to analyze the lipid profile, including triglycerides, total cholesterol, LDL-cholesterol, and HDL-cholesterol.
Time frame: Baseline, 2 months, 1 year, 2 year
Change in blood pressure
Both systolic and diastolic blood pressure will be measure at every time point
Time frame: Baseline, 2 months, 1 year, 2 year
Change in dietary composition
A 4-day food registry will be analyzed at every time point to determine daily energy, macronutrient and micronutrient intake.
Time frame: Baseline, 2 months, 1 year, 2 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.