The goal of this study is to compare the efficacy and adverse events of inhaled isopropyl alcohol vapor (IAV) versus placebo (inhaled eucalyptus scent (IES) (1:20 dilution in mineral oil) for treating nausea associated with acute migraine attacks.
The main goal of this study is to examine the efficacy of (nausea reduction and time to use of other anti-nausea medications) and side effects of inhaled isopropyl alcohol vapor (IAV) for treating nausea among migraine patients using a double blind randomized control methodology. IAV is being compared inhaled eucalyptus scent (IES) (1:20 dilution in mineral oil) which has not shown benefit for treating nausea or migraine and is therefore considered placebo in this study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
50
Eucalyptus oil in mineral (1:20) will be inhaled at least 30 minutes after onset of nausea associated with a migraine attack
Isopropyl Alcohol 70% will be inhaled at least 30 minutes after onset of nausea associated with a migraine attack
HonorHealth Bob Bové Neuroscience Institute
Scottsdale, Arizona, United States
Change of Severity of Nausea on Nausea Scale
Change in Nausea, modified visual analog score from 0-10 with 10 severe nausea with vomiting, 5 moderate nausea, 1 mild nausea and 0 no nausea.
Time frame: ½ hour or to the end of treatment
Side effects associated with interventional substance
Patient written report
Time frame: ½ hour, but likely less than 2 hours
Use of anti-nausea medication/Time to use of anti-nausea medication
Did using IAV vs eucalyptus oil change the time until use of oral anti-emetic?
Time frame: ½ hour or to the end of treatment
Time to Clinically Relevant Nausea Change
Did IAV vs eucalyptus oil reduce the amount of time the patient experienced nausea with their migraine?
Time frame: ½ hour or to the end of treatment
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