In an exploratory observational pilot study, the investigators will focus on the effects of short-term circadian misalignment induced by shift work on multidimensional measurements including glucose excursion, metabolic health, circadian rhythms (measured in vitro and in vivo), sleep/wake cycles and ambient light, eating and activity patterns, well-being and attention.
Study Type
OBSERVATIONAL
Enrollment
72
Detailed questionnaire adapted from the Standard Shiftwork Index, measured at inclusion
Geneva University Hospitals
Geneva, Switzerland
Difference in glucose excursion
As measured by Continuous Glucose Monitoring
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in fasting glucose
As measured by clinical chemistry (mmol/L)
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in weight
Body weight (Kg)
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in waist circumference
Waist circumference (cm) assessed with a measuring tape
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in lipid profile
Total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol measured by clinical chemistry (mmol/L)
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in blood hormonal profile
Insulin (mIU/L), thyroid-stimulating hormone (mIU/L), cortisol (nmol/L) measured by clinical chemistry
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in eating duration
Time from the first to last caloric intake over a 24-hour period
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in nutrient intake
Total calorie and macronutrient intake over a 24-hour period
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in systolic and diastolic blood pressure
As measured by blood pressure arm cuff
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in heart rate variability
As measured by wearable sensor
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in physical activity
As measured by actigraphy and the International Physical Activity Questionnaire
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in sleep/wake cycles
As measured by actigraphy
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in sleep quality
As measured by the Pittsburgh Sleep Quality Index (PSQI), score ranges from 0 to 21 points, 0 indicating no difficulty and 21 severe difficulties
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in attention and sleepiness
As measured by the Sustained Attention to Response Test
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in well-being
As measured by the World Health Organization-5 questionnaire (WHO-5), score ranges from 0 to 25, 0 indicating worst possible and 25 best possible
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months
Difference in mental health outcomes
As measured by the Patient Health Questionnaire-9 (PHQ-9), score ranges from 0 to 27, 0 indicating no depression and 27 severe depression
Time frame: Between a series of day shifts and a series night shifts, separated by an interval from 10 days to 3 months