In this study biomarkers in the blood after exposure to heparin in the fasted state or after a high-fat meal will be investigated. Heparin will be administered as an intravenous (iv) injection (injection directly in a blood vessel). In this study, the effects of administration of heparin will be compared with the effects of administration of normal saline which will also be administered as an iv injection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
12
intravenous \[iv\] injection
Novo Nordisk Investigational Site
Groningen, Netherlands
Change from baseline in Lipoprotein Lipase (LPL) levels before and after heparin exposure both in fasted and postprandial state
ng/ml
Time frame: day -1 to day 6
Change from baseline in LPL activity before and after heparin exposure both in fasted and postprandial state
µmol/l/min
Time frame: day -1 to day 6
Change from baseline in Triglycerides (TG) levels before and after heparin exposure both in fasted and postprandial state
mmol/L
Time frame: day -1 to day 6
Change from baseline in apolipoprotein CII (APOCII) levels before and after heparin exposure both in fasted and postprandial state
mg/L
Time frame: day -1 to day 6
Change from baseline in APOCIII levels before and after heparin exposure both in fasted and postprandial state
mg/dl
Time frame: day -1 to day 6
Change from baseline in total cholesterol levels before and after heparin exposure both in fasted and postprandial state
mmol/L
Time frame: day -1 to day 6
Change from baseline in Free fatty acids (FFA) levels before and after heparin exposure both in fasted and postprandial state
mmol/L
Time frame: day -1 to day 6
Change from baseline in Lipoprotein profiling (very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL), high-density lipoprotein (HDL) before and after heparin exposure both in fasted and postprandial state
mmol.L-1
Time frame: day -1 to day 6
Change from baseline in adverse events (AEs) before and after heparin exposure both in fasted and postprandial state
Number of events
Time frame: day -1 to day 6
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