Surgery or trauma may cause serious problem to patients, especially for senile ones, like postoperative delirium or more postoperative complications. Here, we conduct a investigation of SFI for preventing the happening of POD or postoperative complications.
SFI(Shenfu Injection), a historical medical herbal medicine of traditional Chinese, which may produced much benefit to clinical patients with furtigue after major surgery, because it was a comment sense to think of energy loss if they experience surgical damage. Here, we administrated intravenously SFI into senile patients, who receiving hip fracture surgery, to avoid bad results or serious postoperative outcomes, in case of enhancing recovery after surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
350
Chinese patent medicine made by modern technology
0.9% normal saline, used for sham control
incidence of postoperative delirium within 7 days
postoperative delirium(POD), assessed with Confusion Assessment Method scale and Richmond Agitation-Sedation Scale together.
Time frame: day 1-7 after surgery, more scores means higher incidence of POD
non-delirium complications
postoperative complications except for delirium
Time frame: day 1-7 after surgery
length of stay
length of hospital stay
Time frame: approximately day 1 in hospital to day 7
pain assessment within 3 days
postoperative pain estimated with Numerical Rating Scale
Time frame: day 1-3 after surgery, higher scores mean more pain.
all-caused mortality within 30 days
short-term follow up
Time frame: 30 days after surgery
survival in 1 year
long-term follow up
Time frame: 1 year discharge from hospital
adverse events to shenfu injection
adverse events caused form shenfu injection
Time frame: approximately day1-7 after surgery
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