study the effect of mefanamic acid or valproate on ciprofol
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
41
mefanamic acid once every 6 hours on Day 4 and Day 5, Ciprofol on Day 1 and Day 5
valproate once daily on Day 4 to Day 8, Ciprofol on Day 1 and Day 8
The second affiliated hospital Zhejiang University School of Medicine
Hanzhou, China
effect of mefanamic acid on the Cmax of ciprofol
Peak Plasma Concentration (Cmax)
Time frame: 0-24hour post ciprofol dosing
effect of mefanamic acid on the AUC of ciprofol
Area under the plasma concentration versus time curve (AUC)
Time frame: 0-24hour post ciprofol dosing
effect of valproate on the Cmax of ciprofol
Peak Plasma Concentration (Cmax)
Time frame: 0-24hour post ciprofol dosing
effect of valproate on the AUC of ciprofol
Area under the plasma concentration versus time curve (AUC)
Time frame: 0-24hour post ciprofol dosing
Safety when ciprofol is co-administered with mefanamic acid or valproate
Adverse event
Time frame: 0-24hour post ciprofol dosing
effect of mefanamic acid or valproate on the MOAA/S of ciprofol
MOAA/S
Time frame: 0-24hour post ciprofol dosing
effect of mefanamic acid or valproate on the BIS of ciprofol
BIS
Time frame: 0-24hour post ciprofol dosing
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