Gut Peptides and Bone Remodeling in Individuals With Spinal Cord Injury

University of Copenhagen20 enrolled

Overview

Both GLP-2 and GIP reduce bone resorption (measured as CTX) in healthy persons. In this study, we will investigate whether GLP-2 and GIP is reducing CTX in individuals with spinal cord injury.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Spinal Cord Injuries

Interventions

Meal testOTHER

Ingestion of an oral liquid meal (nutridrink), 200 mL.

GIPOTHER

Subcutaneous GIP injection.

GLP-2OTHER

Subcutaneous GLP-2 injection.

GIP + GLP-2

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria (Individuals with spinal cord injury): * Spinal cord injury resulting in the need of a wheelchair * BMI: 16-32 kg/m2 Inclusion Criteria (Healthy controls): * Intact spinal cord * Matched on gender, age and BMI to the group with spinal cord injury Exclusion Criteria: * Treatment with antidiabetics * Treatment with anti-resorptive agents * Gastrointestinal disease * Smoking * Long term steroid treatment * Weight change more than 3 kg within the last 3 months. * Overweight or intestinal surgery

Locations (1)

Hvidovre University Hospital

Hvidovre, Denmark

RECRUITING