Fascial plane blocks, such as ESP, rely on the spread of local anaesthetic on an interfacial plane, automated boluses may be particularly useful for this group of blocks. However, until recently, ambulatory pumps capable of providing automated boluses in addition to patient-controlled boluses were not widely available. To best of our knowledge, there are no randomised controlled trials comparing continuous infusion versus intermittent bolus strategies for Erector Spinae Plane Block for MITS in terms of patient centred outcomes such as quality of recovery.
Minimally invasive thoracic surgery (MITS) has been shown to reduce postoperative pain, reduce tissue trauma and contribute to better recovery as compared to open thoracotomy. However, it still causes significant acute post-operative pain. Our Mater research group has shown that fascial plane blocks such as the Erector Spinae Plane block (ESP) contribute to post-operative analgesia after MITS. Case reports have described the improved quality of analgesia following ESP using programmed intermittent boluses (PIB) instead of continuous infusion. It is hypothesised that larger, repeated bolus doses provide superior analgesia, possibly as a result of improved spread of the local anaesthetic. Evidence for improved spread of local anaesthetic may be found in one study which demonstrated that PIB increased the number of affected dermatomal levels compared to continuous infusions for continuous paravertebral blocks. Similarly, with regard to labour epidural analgesia, PIB provides better analgesia compared with continuous infusion. Because fascial plane blocks, such as ESP, rely on the spread of local anaesthetic on an interfacial plane, automated boluses may be particularly useful for this group of blocks. However, until recently, ambulatory pumps capable of providing automated boluses in addition to patient-controlled boluses were not widely available. To the best of our knowledge, there are no randomised controlled trials comparing continuous infusion versus intermittent bolus strategies for Erector Spinae Plane Block for MITS in terms of patient-centered outcomes such as quality of recovery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
Programmed Intermittent Bolus (PIB) of Levobupivacaine
Continuous Infusion (CI) of Levobupivacaine
Mater Misericordiae University Hospital
Dublin, Ireland
St Jame's University Hospital
Dublin, Ireland
Quality of Recovery (QoR-15)
Patient centred metric to measure the quality of recovery after surgery. Scale is between 0-150, where '0' refers to poor quality of recovery and '150' refers to excellent quality of recovery
Time frame: 24 hours
Maximal inspiratory volume
This will be measured with a calibrated incentive spirometer at the bedside
Time frame: 48 hours
Area Under the Curve for Verbal Rating Score for pain at rest
Pain scores (0-10). '0' refers to no pain and '10' refers to severe pain.
Time frame: 48 hours
Area Under the Curve for Verbal Rating Score for pain on deep inspiration
Pain scores (0-10). '0' refers to no pain and '10' refers to severe pain.
Time frame: 48 hours
Time to first intravenous opioid
Will be measured from immediate postoperative in minutes
Time frame: 48 hours
Time to first mobilisation
Will be measured from immediate postoperative in hours
Time frame: 48 hours
Duration of time in PACU .
Will be measured from immediate postoperative in minutes
Time frame: 24 hours
Length of hospital stay
Will be measured from immediate postoperative in days
Time frame: 30 days
Quality of Recovery (QoR-15)
Patient centred metric to measure the quality of recovery after surgery. Scale is between 0-150, where '0' refers to poor quality of recovery and '150' refers to excellent quality of recovery
Time frame: 48 hours
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