Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation

Petrovsky National Research Centre of Surgery20 enrolled

Overview

The purpose of this study is to assess the effectiveness and the safety of extracorporeal methods for removing mediators of systemic inflammation in patients with multiple organ dysfunction syndrome after heart and aorta surgery.

After being informed about the study and potential risk, all patients with multiple organ dysfunction syndrome after heart and aorta surgery with indications for extracorporeal removal of inflammatory mediators, giving written informed consent will be included in the study. Patients will be randomized 1:1 ratio to 1. hemoperfusion cartridge for cytokine sorption in combination with an oXiris membrane and 2. oXiris membrane.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Renal Failure Acute Multiple Organ Failure Cardiovascular Diseases

Interventions

renal replacement therapyPROCEDURE

Extracorporeal Methods for Removing Mediators of Systemic Inflammation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * multiple organ dysfunction; * SOFA equal to or more than 4; * CRP equal to or more than 100 ng / ml; * increase of IL6 by 5 times or more Exclusion Criteria: * the impossibility to use heparin ( bleeding; heparin-induced thrombocytopenia)

Locations (1)

Petrovsky Nacional research Centre of Surgery

Moscow, Russia

RECRUITING

Outcomes

Primary Outcomes

CRP

сhange of CRP after 12 hours from baseline value

Time frame: 12 hours from the beginning of the study

CRP

сhange of CRP after 24 hours from baseline value