Treatment of Periodontal Disease in Patients With Alzheimer's Disease

Inclusion Criteria: * Subject has primary school education or above. * Subject has probable AD dementia according to the NIA-AA criteria. * Subject has brain MRI scan consistent with the diagnosis of AD performed during the screening period. Computed Tomography scan can be used only if the subject has an absolute contraindication for MRI. * Subject has a Modified Hachinski score ≤4 at screening. * Subject has an MMSE score ≥15 at screening. * Subjects with background symptomatic therapy with acetylcholine esterase inhibitors, and/or memantine, are allowed as long as the dose has been stable for 90 days prior to screening and no changes are planned during the study. * Subject has a primary caregiver willing to accept responsibility for supervising the treatment (e.g., administering study drug) and assessing the condition of the subject throughout the study in accordance with all protocol requirements. * Subject has body mass index \<38 kg/m2 at Screening Exclusion Criteria: * Subject has imaging consistent with a dementia diagnosis other than AD. * Subject has had an increase or restoration of cognition based on medical history. * Subject with history or current evidence of major psychiatric illness such as schizophrenia, bipolar disorder, or major depressive disorder that may interfere with the patient's ability to perform the study and all assessments. NOTE: Mild depression or depressive mood arising in the context of AD are not criteria for exclusion. The use of anti-depressants or the use of anti epileptic medication for non seizure-related treatment is allowed if the dose has remained stable for at least 60 days prior to enrollment. * Subject is fitted with pacemakers (except for new compatible products), large ferromagnetic implants, or implanted electronic devices such as cochlear implants, magnetic metal drug infusion pumps, nerve stimulators, diaphragmatic stimulators and injection pumps, physiological stimulators, and cardiac mechanical valves. * Subject has magnetic metal foreign body or prosthesis in eye, magnetic metal joint or ferromagnetic foreign body in body. * Subject has epilepsy or claustrophobia. * Subject had received antibiotics or periodontal treatment within the last 6 months. * Subject had taken aspirin, warfarin and other anticoagulant drugs in the last 6 months. * Subject has any of the following laboratory findings at screening: 1. Coagulation disorders. 2. Hemoglobin ≤10 g/dl. 3. Poorly controlled diabetes as defined by hemoglobin A1C (HbA1C) \>8. 4. Positive blood screen for Human Immunodeficiency Virus (HIV 1 and 2), Hepatitis B surface antigen (HBsAg), or Hepatitis C virus antibodies (HCV-Ab) at Screening.