Bioavailability of Orally Ingested Vitamin C

University of Exeter

Overview

The purpose of this study is to determine if crystalline vitamin C supplementation can acutely increase skeletal muscle vitamin C concentrations and if this can be potentiated by administering vitamin C using Phosphycell™ Technology - a phosphatidylcholine-lipid encapsulation technology.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Conditions

Healthy

Interventions

Phosphatidylcholine-lipid encapsulated vitamin CDIETARY_SUPPLEMENT

Ingesting 1000 mg of vitamin C in phosphatidylcholine-lipid encapsulated form

Crystalline vitamin CDIETARY_SUPPLEMENT

Ingesting 1000 mg of vitamin C in crystalline form

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Body mass index (BMI) 18.5 - 30 kg/m2 * Age 18 - 40 * Non-smoker Exclusion Criteria: * Body mass index (BMI) \< 18.5 or \> 30 kg/m2 * Age \< 18 or \> 40 * Smoking * Cardiovascular disease * Hypertension (≥ 140/90 mmHg) * Metabolic disease * Medications known to affect vitamin C metabolism * A known vitamin C deficiency * Less than 2 hours per week of physical activity or following a structured exercise training program. * Routine use of vitamin supplements

Locations (1)

Sport and Health Sciences

Exeter, Devon, United Kingdom

Outcomes

Primary Outcomes

Skeletal muscle vitamin C concentrations

Skeletal muscle vitamin C concentrations 6 hours after vitamin C ingestion will be measured using HPLC and compared to baseline

Time frame: 6 hours after vitamin C ingestion

Skeletal muscle vitamin C concentrations

Skeletal muscle vitamin C concentrations 12 hours after vitamin C ingestion will be measured using HPLC and compared to baseline and 6 hours after vitamin C ingestion

Time frame: 12 hours after vitamin C ingestion

Secondary Outcomes

Blood plasma vitamin C concentrations

Blood plasma vitamin C concentrations will be measured using HPLC during the 24 hour post vitamin C ingestion period

Time frame: 24 hours after vitamin C ingestion

White blood cell vitamin C concentrations

White blood cell vitamin C concentrations will be measured 6 hours after vitamin C ingestion using HPLC and compared to baseline

Time frame: 6 hours after vitamin C ingestion

White blood cell vitamin C concentrations

White blood cell vitamin C concentrations will be measured 24 hours after vitamin C ingestion using HPLC and compared to baseline and 3 hours post vitamin C ingestion

Time frame: 24 hours after vitamin C ingestion

Cardiovascular function

Cardiovascular function will be measuring using a finger plethysmograph during the 24 hour post vitamin C ingestion period

Time frame: 24 hours after vitamin C ingestion

Data from ClinicalTrials.gov

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