The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis. The investigators will study the effect of Endocalyx on endothelial, vascular and left ventricular myocardial function in patients with psoriatic disease.
Sixty patients with psoriatic disease, who are referred to the outpatient psoriasis clinic of the Attikon University Hospital, will be randomized to receive food supplement Endocalyx (4 capsules per day) (n=30) or placebo (n=30) for 4 consecutive months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
60
Patients with psoriatic disease will be randomized to receive food supplement Endocalyx for 4 months.
Patients with psoriatic disease will be randomized to receive placebo for 4 months.
Attikon University Hospital
Athens, Attica, Greece
RECRUITINGEndocalyx effects on endothelial glycocalyx thickness
Endocalyx effects on endothelial glycocalyx thickness as assessed by perfused boundary region (PBR, micrometers) of the sublingual arterial microvessels using Sidestream Dark Field (SDF) imaging.
Time frame: four months
Endocalyx effects on arterial stiffness
Endocalyx effects on arterial stiffness as assessed by carotid to femoral pulse wave velocity (PWV, m/s) using tonometry.
Time frame: four months
Endocalyx effects on coronary microcirculation
Endocalyx effects on coronary function as assessed by measuring coronary flow reserve of left anterior descending artery. Coronary flow reserve is estimated by Doppler echocardiography as the ratio of coronary flow velocity after bolus intravenous adenosine infusion to coronary flow velocity at rest.
Time frame: four months
Endocalyx effects on left ventricular myocardial function
Endocalyx effects on left ventricular function as assessed by global longitudinal strain using speckle-tracking echocardiography.
Time frame: four months
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