Effects of Propofol-Induced Anaesthesia on the ST-segment of the ECG

Universitair Ziekenhuis Brussel500 enrolled

Overview

The purpose of this study is to assess the effect of propofol induced general anaesthesia on the ST-segment of the electrocardiogram. This will be realised by retrospectively analysing the ECG-recordings from adult patients undergoing any treatment at the Catheterisation Laboratory. The ST-segment and other ECG measurements from induction of anaesthesia up to 20 minutes later, will be assessed and compared to the baseline values of the respective segments acquired before injecting propofol. It is essential in this study to exclude any patients burdened with the diagnosis, suspicion or family history of Brugada syndrome.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

No Specific Condition (Patients Without Brugada Syndrome)

Interventions

Observational studyOTHER

Retrospective data-analysis

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Induction of anaesthesia with propofol * Monitored anaesthesia in the CathLab of the Universitair Ziekenhuis Brussel Exclusion Criteria: * Brugada Syndrome or family history of Brugada syndrome * Paediatric population (age \<18) * Patients who did not receive propofol during the procedure * Patients who presented with fever (central core temperature \>38,0°C)

Outcomes

Primary Outcomes

ST-segment variations after propofol administration.

Determine ST-segment variations in mm (either augmentation or suppression) on the ECG in the 20 minute period after administration of propofol in comparison to the baseline ECG

Time frame: Baseline ECG will be measured before administration of propofol. ECG will be measured in the 20 minutes following administration of propofol

Secondary Outcomes

Additional ECG-segment variations after propofol administration

Assess additional ECG-segments measurements in mm and ms from the ECGs recorded. These include Jp- (mm), QRS- (ms), T(p-e)-segments (ms) and the T(p-e)/QT ratio.