Study for Rapid Diagnosis of Postoperative Abdominal Infection

Peking Union Medical College Hospital30 enrolled

Overview

This is a prospective and exploratory study, which utilizes non-targeted metagenomic next-generation sequencing (mNGS) detecting drain fluid from patients who are suspected of postoperative abdominal infection. This study aims to explore the clinical value of mNGS in the rapid diagnosis of postoperative abdominal infection, to refine the pathogenic bacteria spectrum, and to establish a novel procedure for postoperative abdominal infection diagnosis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Postoperative Infection Abdominal Surgery Intra-abdominal Infection Postoperative Fever

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients who receive abdominal operations with routinely abdominal drainage placement. 2. Abdominal infection is suspected by the clinicians, and one of the following conditions is met: 1. Temperature ≥38℃; 2. One of the following laboratory indicators: WBC≥10×10\^9/L, PCT≥0.5ng/ml, hsCRP≥100mg/L. Exclusion Criteria: 1. Patients who are diagnosed with the abdominal infection before surgery. 2. Evidence of non-abdominal infection is clear and could explain the clinical symptoms.

Outcomes

Primary Outcomes

The pathogenic spectrum of postoperative abdominal infection

Time frame: Through study completion, an average of 1 year

Secondary Outcomes

Consistency between mNGS and conventional culture methods