Fitness Assessment in Young Adults Recovered From Lymphoma

University Hospital, Clermont-Ferrand44 enrolled

Overview

Regular physical activity (PA) is associated with maintaining body composition, increased cardiorespiratory capacity, muscle mass and bone mineral density. In the event of a cancer, the development of physical capacities and metabolism may therefore be disturbed by cancer, these associated treatments (chemotherapy, radiotherapy and hematopoietic stem cell transplantation) but also undernutrition and the reduction in physical activity or even a sedentary lifestyle. Although the benefits of PA in oncology are now well identified for adult populations, studies are still rare in the population of children, adolescents and young adults, and the results are still difficult to generalize. As a result, there is no recommendation on the practice of physical activity in pediatric oncology or adolescents and young adults and the levels of physical activity of cured patients remain lower than those of the general population. Fitness is a marker of health in adults as well as in adolescents. Physical condition is a set of components such as cardiorespiratory capacity (transport and use of O2), body composition (distribution of bone, muscle and fat masses) and muscle function (strength, power, fatigue, energy metabolism) . The investigators hypothesize that, compared to young adults, recovered from lymphoma are expected to exhibit impaired physical condition, due to physical deconditioning.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Young Adults

Interventions

Indirect calorimetric test during submaximal exerciseOTHER

* metabolic evaluation by indirect calorimetry at rest and during exercise * evaluation of cardiac output * peripheral quantitative computed tomography (pQCT) of the muscle cross section * evaluation of body composition * assessment of physical capacity (chair test and 3 min step-test) * blood test * assess the level of physical activity

Eligibility

Sex: ALLMin age: 18 YearsMax age: 25 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Young adult male or female, aged 18 to 25 * giving free and informed consent * Hodgkin lymphoma or non-Hodgkin lymphoma in the healing stage * Cured (defined by an undetectable disease at the end of treatment) for at least one year and maximum 6 years of lymphoma or Hodgkin's disease Exclusion Criteria: * Legal incapable adults * People under judicial protection * Treatment with systemic glucocorticoids for more than a week, during the 30 days preceding the tests * Medical contraindication to the practice of physical exercise * Any pathologies (other than the history of lymphoma for the cases) likely to affect the metabolism or the muscle mass * Any treatment that may have an influence on the energy metabolism * Active infection * Pregnant, breastfeeding, or likely to be * Subject's refusal to participate

Outcomes

Primary Outcomes

fat oxidation rate

maximum rate of lipid oxidation (in mg/ml)

Time frame: day at 11:30 am during one day

Secondary Outcomes

rest metabolism

energy expenditure at rest in kcal.

Time frame: at 08:00 am in fasted condition during one day

blood insulinemia

blood value of insulin in pmol/L