The aim of the present study was to investigate the effect of intervention with Lactobacillus paracasei K56 on body fat, metabolic risk markers,inflammatory markers and gut microbiota composition in obesity.
Recent data suggest that gut microbiota can function as an environmental factor that modulates the amount of body fat and obese individuals have an altered gut microbiota.The results of previous animal studies have suggest that a probiotic strain Lactobacillus paracasei K56 have reduced high-fat diet induced obesity. In this randomised,double blind ,placebo controlled study, the participants were randomly assigned to probiotic K56 group or placebo group to evaluate the fat-reducing effect of the Lactobacillus paracasei K56 by continuously supplementing probiotic or placebo capsules.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
120
probiotic K56 capsule, 1capsule/day (10\^9cfu) ,for 60days
placebo capsule(maltodextrin) , 1capsule/day ,for 60days
Hua Dong Hospital Affiliated to Fu Dan University
Shanghai, China
RECRUITINGvisceral fat area (cm^2)
VFA (cm\^2) will be assessed at baseline and after 60days of intervention
Time frame: 60days
percent body fat (%)
PBF (%) will be assessed at baseline and after 60days of intervention
Time frame: 60days
body weight
Body weight (kg) will be assessed at baseline and after 60days of intervention
Time frame: 60days
Body Mass Index BMI
Body Mass Index (kg/m\^2) will be assessed at baseline and after 60days of intervention
Time frame: 60 days
waist circumference (cm)
will be assessed at baseline and after 60days of intervention
Time frame: Baseline, 60 days
hip circumference(cm)
will be assessed at baseline and after 60days of intervention
Time frame: 60 days
waist to hip ratio (WHR)
waist to hip ratio (WHR) will be assessed at baseline and after 60days of intervention
Time frame: 60 days
Serum Lipid Profile
Serum total cholesterol(mmol/L),Serum triglycerides(mmol/L),Low-density lipoprotein(mmol/L),High density lipoprotein(mmol/L) will be measured at baseline and after 60days of intervention
Time frame: 60 days
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fasting blood glucose
fasting blood glucose(mmol/L) will be measured at baseline and after 60days of intervention
Time frame: 60 days
Glycated hemoglobin
Glycated hemoglobin(%) will be measured at baseline and after 60days of intervention
Time frame: 60 days
Glycosylated albumin
Glycosylated albumin(%) will be measured at baseline and after 60days of intervention
Time frame: 60days