Given the early literature available and its biological plausibility as an inhibitor of the mammalian target of rapamycin (mTOR) protein, it is hypothesized that women with endometrial cancer who take metformin for non-cancer related reasons have a lower cancer recurrence rate compared to women not taking metformin. The primary goal of this study is to determine whether metformin use is associated with a decrease in the rate of endometrial cancer recurrence. Secondary objectives are to assess whether women with endometrial cancer taking metformin have longer progression free survival and overall survival than those that do not take metformin.
This is a retrospective chart review study. Medical records are reviewed and data collected through the hospital's electronic medical record (EMR). Participants are women that had definitive treatment for endometrial cancer between 2016-2020 at WellSpan York Hospital Department of Gynecologic Oncology. Participants are identified and their chart reviewed for demographic data of age, race, comorbid conditions, and use of metformin. Possible confounding information is documented, including chemotherapy status, radiotherapy status, cancer and tumor type, grade, and stage, available genetics information, medications at the time of cancer diagnosis, and medication durations. Those patients who had cancer recurrence are identified. Recurrence data including type, time interval, additional treatment are collected. Recurrence is defined as any recurrence validated by clinical, imaging and histological data and can be identified based on the cancer registry. Recurrence rate in participants that took metformin vs. those that did not is calculated. Time to endometrial cancer recurrence is calculated. Progression free survival and overall survival are calculated. Statistical analysis is performed to compare each of these outcomes between participants who took metformin vs. those that did not.
Study Type
OBSERVATIONAL
As an observational study, this is past exposure to metformin that occurred during the study period
WellSpan
York, Pennsylvania, United States
Endometrial Cancer Recurrence
This is the identification of whether metformin use is associated with endometrial cancer recurrence.
Time frame: 2016-2020
Progression Free Survival
This is the identification of whether metformin use is associated with improved progression free survival of endometrial cancer.
Time frame: 2016-2020
Overall Survival
This is the identification of whether metformin use is associated with improved overall survival of endometrial cancer.
Time frame: 2016-2020
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.