Analysis of outcomes and adverse events of patients undergoing radiation therapy. Quality control using data base of patient records 2000-2025
What are the findings of the systematic recording and analysis of the outcomes and adverse events of radiotherapy, and how do these findings improve radiotherapy for future patients? The goals of the systematic collection and analysis of patient-related personal data include: * Quality assurance and showing where the quality can be improved * Recording the outcomes and side effect profile of radiotherapy and adapting to prevent serious side effects in the future * Presentation and publication as part of the clinical research program at the Institute for Radio-Oncology of the Winterthur Cantonal Hospital
Study Type
OBSERVATIONAL
Enrollment
25,000
Outcomes and adverse events using radiation therapy
Kantonsspital Winterthur
Winterthur, Canton of Zurich, Switzerland
RECRUITINGOverall survival (OS) and progression free survival (PFS) analysis after radiation therapy
Calculation of Overall survival (OS) and progression free survival (PFS). Time-to-event endpoints are summarized as the median and corresponding 95% confidence interval using Kaplan-Meier method
Time frame: 25 years
Analysis of risk factors influencing outcome after radiation therapy
Calculation of log-rank tests. If possible, hazard ratios are calculated via Cox regression. Competing risk analysis is conducted as supportive analysis
Time frame: 25 years
Number of patients with acute and late adverse events after radiation therapy
Predefined toxicity events are described by type, grade, frequency, and percentage across all time points. Fisher's exact tests are used for comparison (base line and defined time points). Quality of life symptom and function scales are used. Two-tailed tests with a significance level of 0.05 are used for all analyses. Adjustments for multiple testing may be used. Some of the analyses are exploratory and hypothesis generating
Time frame: 25 years
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