Curative-intent therapies for hepatocellular carcinoma (HCC) include radiofrequency ablation (RFA), liver resection (LR), and liver transplantation (LT). Controversy exists in treatment selection for early-stage tumors. We sought to evaluate the oncologic outcomes of patients who received either RFA, LR, or LT as first-line treatment for solitary HCC ≤ 3cm in an intention-to-treat analysis.
Study Type
OBSERVATIONAL
Enrollment
119
Treatment-naive patients with solitary HCC \<= 3 cm who received ablation as the first-line treatment
Treatment-naive patients with solitary HCC \<= 3 cm who underwent liver resection as the first-line treatment
Treatment-naive patients with solitary HCC \<= 3 cm who were listed for liver transplantation as the first-line treatment
Intention-to-treat (ITT) overall survival
ITT was evaluated from the first treatment modality that was selected for curative intent. In the case of RFA and LR this was recorded as the time of the treatment. In the case of LT, the intention-to-treat was recorded at the time of listing for transplantation. The ITT analysis thus accounted for patients who were placed on the waitlist but dropped out.
Time frame: Overall (median length of follow up of entire cohort 6.6 years)
Disease-free survival (DFS).
DFS was defined as the time after treatment during which the patient was alive and free of disease. For DFS, patients were censored at recurrence, death, or loss to follow up.
Time frame: Overall (median length of follow up of entire cohort 6.6 years)
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