The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma to evaluate effects of beta blocker on patients with TBI.
The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma . Patients will be randomly assigned into two groups by sealed envelope technique into two equal groups. Parameters assessment: * Length of ICU stay * Length of total hospital stay * CT scan to exclude another intracranial hemorrhage or increase in hemorrhage * Functional status will be assessed using the GCS * Hemodynamic data ( bl.p / hr ) * Crystalloid volume that patient need in 24h * Mortality rate
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
40
intravenous propranolol for case patients
intravenous saline for placebo
Faculty of Medicine, University Hospitals
Shibīn al Kawm, Menoufia, Egypt
survival
number of surviving in patients receiving propranolol and patients who did not receive any beta blocker
Time frame: 7 days
heart rate
number of patient showing effect of beta blocker on TBI related to HR
Time frame: 7 days
icu stay
number of patients were beta blocker in TBI affected on ICU and total hospital stay
Time frame: 7 days
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