Efficacy and Safety of Substitution of Glucocorticoid for BDB-001 Injection in Patients With Anti-neutrophil Cytoplasmic Antibody(ANCA)-Associated Vasculitis

Inclusion Criteria: * 18 years old≤Age≤75 years old, male or female; * Diagnosis of granulomatosis with polyangiitis(GPA) or microscopic polyangiitis(MPA)； * Newly diagnosed or relapsed GPA or MPA that requires treatment with cyclophosphamide(CYC) and glucocorticoids(GCs)； * Positive test for anti-proteinase 3(PR3) or anti-myeloperoxidase (MPO)； * Estimated glomerular filtration rate ≥15 mL/minute/1.73 m\^2； * At least 1 major item, or at least 3 non-major items, or at least the 2 renal items on BVAS； Exclusion Criteria: * Active tuberculosis infection; * Severe disease as determined by rapidly progressive glomerulonephritis, alveolar hemorrhage requiring pulmonary ventilation support, rapid-onset mononeuritis multiplex or central nervous system involvement； * Any other known multi-system autoimmune disease including eosinophilic granulomatosis with polyangiitis (Churg-Strauss), systemic lupus erythematosus, IgA vasculitis (Henoch-Schönlein), rheumatoid vasculitis,anti-glomerular basement membrane disease, or cryoglobulinemic vasculitis； * HBsAg positive,or HBcAb positive and HBV-DNA positive； * Received CYC within 3 months before the first administration or Received rituximab(RTX) within 12 months before the first administration； * Received glucocorticoid shock therapy within 4 weeks before the first administration； * Received an oral daily dose of a GC of \> 10 mg prednisone-equivalent for more than 6 weeks continuously before the first administration； * Received a anti-tumor necrosis factor and other biological agents treatment within 12 weeks before the first administration； * Received Continuous dialysis treatment for 12 weeks or more before the first administration; Received Dialysis within 1 week before the first administration; * Received intravenous immunoglobulin (Ig) or plasma exchange within 4 weeks before the first administration; * Pregnant or lactating.