Some studies suggest the prescription of aromatase inhibitors prior to the use of misoprostol for inducing drug abortion. the aim of the study is to compare the effectiveness of various regimens of letrozole combined with misoprostol versus using misoprostol alone in inducing complete abortion in patients with blighted ovum.
Some studies suggest prescription of aromatase inhibitors prior to the use of misoprostol for inducing drug abortion, increases the efficiency of the treatment regimen and also decreases the need for surgical interventions. Some conducted studies have mentioned reinforcing the impact of misoprostol with letrozole, but reaching the ideal dose still needs more studies, so in this study, the investigators will compare the effectiveness of various regimens of letrozole ( 10 mg/d for 3 days or a single dose of 20 mg) combined with misoprostol versus using misoprostol alone in inducing complete abortion in patients with a blighted ovum.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Enrollment
96
Letrozole is a third-generation non-steroidal aromatase inhibitor
a synthetic prostaglandin medication
Placebo tables with a similar appearance to letrozole
Cairo University
Cairo, Egypt
Complete abortion
no emergency or elective curettage was necessary until next menstruation
Time frame: 2 days
Induction-to-abortion interval
the interval between administration of misoprostol)
Time frame: 2 days
Adverse effects of Misoprostol
diarrhea, abdominal cramps, fever and sweating.
Time frame: 2 days
Adverse effects of Letrozole
hot flushes, drowsiness and nausea.
Time frame: 2 days
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