The injuries induced by Human Papillomavirus (HPV) (anogenital condyloma mainly) are more frequent among transplanted patients due to their immunosuppression. These injuries are benign but they have a negative impact on the patients' quality of life. The initial treatment is topical and then surgical. The injuries can relapse, especially among transplanted patients. The modification of the immunosuppressant treatment with a switch to mTOR inhibitors (mammalian Target Of Rapamycin) has shown its efficacy in preventing the recurrence of squamous cell carcinomas or treating Kaposi's disease. By analogy, this therapeutic strategy can be sometimes put forward to transplanted patients with HPV-induced injuries. The principal objective of this study is to describe the evolution of HPV-induced lesions in solid organ transplant patients.
Study Type
OBSERVATIONAL
Enrollment
45
The outcome measure is the evolution of HPV related lesions between : * favourable evolution including partial or total regression * unfavourable evolution including non-evolution or aggravation or recurrence.
Hôpital Edouard Herriot
Lyon, Auvergne-Rhône-Alpes, France
Evolution of HPV related lesions in patient with switch
At one year of the switch by an inhibitor of mTOR then remotely of the switch (by tacking the last medical encounter) for the patients concerned by the switch.
Time frame: at inclusion
Evolution of HPV related lesions in patient without switch
At one year of the first HPV related lesions care then remotely (by tacking the last medical encounter) for the patients without the switch.
Time frame: at inclusion
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.