The research study is a parallel arm, randomized placebo-controlled clinical trial designed to assess changes in hepatic lipid accumulation, visceral adipose tissue and postprandial lipid, markers of inflammation and energy metabolism in participants who consume 3 study foods per day for 16 week, while maintaining their body weight.
The study objectives include: 1. To determine the impact of dietary soybean oil on ectopic liver fat and visceral adipose in adults with nonalcoholic fatty liver disease (NAFLD) or similar diagnosis 2. To evaluate the effect of soybean oil supplementation on postprandial lipids, markers of inflammation and energy metabolism 3. To measure the strength of the association of change in plasma linoleic acid with changes in ectopic liver fat, visceral adipose, and postprandial lipids, markers of inflammation and energy metabolism 4. To explore emerging mechanistic targets of LA-rich soybean oils that are linked with reduced liver fat and better cardiometabolic health
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
74
Three food product containing 10g of soybean oil each will be consumed each day for a today of 30g of soybean oil consumed each day
Three food product containing 10g of palm oil each will be consumed each day for a today of 30g of palm oil consumed each day
The Ohio State University Human Nutrition Laboratory
Columbus, Ohio, United States
Changes in ectopic liver lipids
To determine the impact of dietary soybean oil on ectopic liver fat measured through MRI
Time frame: Week 0 and Week 16
Changes in visceral adipose tissue
To determine the impact of dietary soybean oil on visceral adipose tissue measured through MRI
Time frame: Week 0 and Week 16
Changes in postprandial lipids
To evaluate the effect of soybean oil supplementation on postprandial lipid panel including total cholesterol, HDL-Cholesterol, LDL-Cholesterol, Triglycerides
Time frame: Week 0 and Week 16
Changes in postprandial markers of inflammation
To evaluate the effect of soybean oil supplementation on the postprandial IL-6, Tumor necrosis factor, and C-reactive protein in the blood
Time frame: Week 0 and Week 16
Changes in postprandial energy metabolism
To evaluate the effect of soybean oil supplementation on postprandial indirect calorimetry or respiratory gas exchange
Time frame: Week 0 and Week 16
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