Effect of Colchicine On Left Ventricle Function After Anterior Myocardial Infarction Assessed By Speckle Tracking

Phase 4CompletedNCT05200052

Ain Shams University100 enrolled

Overview

Effect of colchicine use on Left ventricles systolic function in patients with anterior S-T elevation myocardial infarction undergoing primary Percutaneous coronary intervention by using speckle tracking Echocardiography longitudinal strain pattern

The study participants are patients presented with anterior myocardial infarction. They will be divided into 2 groups. The first group will receive colchicine loading dose of 1mg then 0.5 mg maintenance dose in addition to the standard anti ischemic treatment for 6 months. The other group will only receive the standard anti ischmic treatment. Speckle tracking echocardiography will be done to all patients to assess left ventricular longitudinal strain pattern.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Anterior MI Colchicine

Interventions

Colchicine 0.5 mg Oral TabletDRUG

Colchicine loading dose 1 mg and maintenance dose 0.5 mg for 6 months in addition to standard anti ischemic treatment.

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: ▪︎Anterior S-T segment elevation myocardial infarction with time of presentation less than 12 hours. Exclusion Criteria: * Severe renal impairment. * Cardiac arrest. * Cardiogenic shock.

Locations (1)

Ain Shams University hospitals

Cairo, Egypt

Outcomes

Primary Outcomes

Average of global longitudinal strain pattern

Assessment of left ventricular longitudinal strain by speckle tracking echocardiography after beforr and after colchicine

Time frame: 6 months

Secondary Outcomes

Number of mortality during study

Death from any cause

Time frame: 6 months

Data from ClinicalTrials.gov

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