Deep Inspiration Breath-hold Radiotherapy for Left-sided Breast Cancer

N/AUnknownNCT05200078

Shu lian Wang166 enrolled

Overview

Postoperative breast radiotherapy (RT) has been associated with increased risk of heart toxicity. However, there is a lack of knowledge for radiation-induced early cardiovascular injury, especially for hypofractionated RT. This study aims to prospectively detect and predict early clinical or subclinical cardiac events in women undergoing adjuvant RT for breast cancer.

Women with left-sided breast cancer undergo hypofractionated RT at either free-breathing or deep inspiration breath-hold. The incidence and potential clinical, dosimetric and biological indicators of early clinical or subclinical cardiac injury are investigate at 2 years.

Study Type

OBSERVATIONAL

Enrollment

166

Conditions

Breast Cancer Cardiac Event

Interventions

Deep inspiration breath-hold techniqueDEVICE

Selective application of deep inspiration breath-hold technique

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Primary left-sided breast cancer post surgery * Planning for adjuvant breast/chest wall +-RNI Exclusion Criteria: * History of cardiovascular disease * Previous chest radiation * Bilateral breast cancers

Locations (1)

Cancer Hospital, Chinese Academy of Medical Sciences

Beijing, China

RECRUITING

Outcomes

Primary Outcomes

Incidence of clinical or subclinical cardiac injury

predefined cardiac events

Time frame: two years

Central Contacts

Shu-Lian Wang

CONTACT

86-13366191993 wangsl@cicams.ac.cn

Data from ClinicalTrials.gov

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