A randomized controlled trial will be conducted. Patients with asymptomatic intracranial / carotid stenosis will be randomized into two arms (1:1): an intervention arm and a control arm. Patients in the intervention arm will be treated with standard medical treatment combined with Natto Products V, whereas Patient in the control arm will be treated with only standard medical treatment . And the impact of Natto Products V on improving cerebral blood flow and cognitive function in patients with asymptomatic intracranial / carotid stenosis will be assessed by neuropsychological scale and multimode magnetic resonance imaging.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
100
Nattokinase + standard treatment
Placebo+ standard treatment
Second Affilated Hospital of Zhejiang University, School of Medicine
Hangzhou, Zhejiang, China
RECRUITINGChanges in the scores of Montreal Cognitive Assessment
Total score of 30
Time frame: 6 months
Changes in the scores of Mini-mental State Examination
Total score of 30
Time frame: 6 months
Changes in cerebral blood flow in the territory of the culprit artery
Time frame: 6 months
Changes in the scores of Colour Trail Test
Time frame: 6 months
Changes in the scores of Hopkins Verbal Learning Test
Time frame: 6 months
Changes in the scores of clock drawing test
Time frame: 6 months
Changes in the scores of Animal Fluency Test
Time frame: 6 months
Changes in the scores of Olfactory stick test
Time frame: 6 months
Incidence of stroke event including ischemic and hemorrhagic stroke
Time frame: 6 months
Changes in cerebral glymphatic function
assessed by non-invasive diffusion tensor image analysis along the perivascular space (ALPS-index)
Time frame: 6 months
Changes in metabonomics
include blood and fecal samples
Time frame: 6 months
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