A Phase I Study to Assess the Pharmacokinetics of Olorofim in Subjects With Renal Impairment

Inclusion Criteria: * Male or female subjects 18 to 70 years of age inclusive, at the time of signing the informed consent. * Body weight ≥50 kg and BMI within the range 18 to 35 kg/m2 (inclusive) * Subjects with severe renal impairment (or End-Stage Renal Disease who are not on dialysis) and with an eGFR \<30 mL/min, estimated using the Cockcroft-Gault equation at screening and Day -1 * Subjects with normal renal function must be in good health, as determined by a medical history, physical examination, vital signs, 12-lead ECG, and clinical laboratory evaluations * Subjects with normal renal function are matched by gender, age (±10 years) and BMI (± 20%) to at least one renally impaired subject. Exclusion Criteria: * Subjects who have an abnormality in the 12-lead ECG that, in the opinion of the Investigator, increases the risk of participating in the study * Subjects with any history of convulsion (other than childhood febrile convulsion before the age of 6 years). * Subjects who have any clinically significant allergic disease (excluding mild or seasonal allergies such as contact dermatitis or hay fever) as determined by the Investigator. * Subjects with a history of or any concomitant active malignancy. * Subjects with a history of drug or alcohol abuse. * Subjects with, or with a history of, any clinically significant neurological, hepatic, cardiovascular, psychiatric, respiratory, metabolic, endocrine, ocular (including minor trauma), hematological, or other major disorders as determined by the Investigator. * Subjects with signs or symptoms consistent with a COVID-19 infection at screening or Day -1 * Renally impaired subjects with kidney transplantation, or on dialysis