Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) may represent as a sensitive and robust tool to detect early changes in brain subtle structures and functions. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.
Cerebral small vessel disease (cSVD) accounts for 20% of ischemic strokes and is the most common cause of vascular cognitive impairment. Early identification of cSVD is critical for early intervention and improve clinical outcomes. Magnetic resonance imaging (MRI) is sensitive to change in white matter structure and subtle vascular function alternation which correlates with cognition impairments in cSVD. MRI manifestation may also represent as useful surrogate marker. Development of advanced MRI technologies promotes their invaluable application in brain and vascular qualitative and quantitative assessment. The study is to investigate the comprehensive evaluation of brain structures and vascular functions by using advanced MRI technologies in early diagnosis and management of cSVD.
Study Type
OBSERVATIONAL
Enrollment
300
Patients recruited will receive Magnetic resonance imaging.
Chinese PLA General Hospital
Beijing, China
RECRUITINGProgression in total cerebral small vessel disease burden
Total cSVD burden assessed by MRI
Time frame: 1 year
Progression in congnitive impairments
Global Z-score by cognitive domain
Time frame: 1 years
Recurrent ischemic events
Recurrent ischemic stroke, TIA and vascular death
Time frame: 1 year
Modified Rankin Scale
Disability assessed by modified Rankin Scale (mRS). The scores, ranging from 0 (no symptoms) to 6 (death), were recorded by phone call or outpatient consultation. A favorable outcome was defined as mRS score 0-2, unfavorable outcome was defined as mRS score \> 2.
Time frame: 90 days and 1 year after qualifying event
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