The purpose of this study is to investigate how the drug Lu AG06466 is absorbed, metabolized, and excreted from the body, for example, what the body does to the drug after swallowing a single dose.
Researchers will measure the levels of the drug and its breakdown product in each participants blood for up to 5 days after dosing. Radioactivity in urine and feces will be measured for up to 3.5 weeks after dosing.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
6
\[14C\]-Lu AG06466 will be administered per schedule specified in the arm description.
LabCorp Clinical Research Unit Ltd
Leeds, United Kingdom
Cumulative Percent Recovery of Radioactivity in Urine
Time frame: From Day 1 to Day 23
Cumulative Percent Recovery of Radioactivity in Faeces
Time frame: From Day 1 to Day 23
Total Cumulative Percent Recovery of Radioactivity in Urine and Faeces
Time frame: From Day 1 to Day 23
Area Under the Plasma Concentration-Time Curve From Time 0 to Infinity (AUC0-inf) of Lu AG06466
Time frame: 0 (predose) up to 96 hours postdose on Day 1 to Day 5
AUC0-inf of Metabolite Lu AG06988 in Plasma
Time frame: 0 (predose) up to 96 hours postdose on Day 1 to Day 5
Maximum Observed Concentration (Cmax) of Lu AG06466 in Plasma
Time frame: 0 (predose) up to 96 hours postdose on Day 1 to Day 5
Cmax of Metabolite Lu AG0988 in Plasma
Time frame: 0 (predose) up to 96 hours postdose on Day 1 to Day 5
Time to Reach Cmax (tmax) of Lu AG06466
Time frame: 0 (predose) up to 96 hours postdose on Day 1 to Day 5
Tmax of Metabolite Lu AG06988
Time frame: 0 (predose) up to 96 hours postdose on Day 1 to Day 5
Apparent Elimination Half-life (t1/2) of Lu AG06466 in Plasma
Time frame: 0 (predose) up to 96 hours postdose on Day 1 to Day 5
t1/2 of Metabolite Lu AG06988 in Plasma
Time frame: 0 (predose) up to 96 hours postdose on Day 1 to Day 5
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