Effect of Muscle and Skin Fixation of Thoracic Drainage Tube on Postoperative Pain

N/AUnknownNCT05202249

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University60 enrolled

Overview

Lung cancer is the leading cause of cancer-related death worldwide. Thoracoscopic pulmonary resection is a prevalent management for early stage of lung cancer. Placement of chest tube is the standard procedure after surgery, which causes pain that cannot be ignored. The investigators aimed to determine whether a muscle layer fixation of thoracic drainage tube could release postoperative pain in patients with uniport thoracoscopic pulmonary resection compared with conventional skin fixation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Lung Neoplasms Lung Cancer Pulmonary Neoplasm Postoperative Pain Thoracoscopic Surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18\<age\<80; * ASA≤III * Patients with no clinically significant cardiac history, such as ischaemic heart disease, valvular heart disease, rhythm disturbances such as frequent atrial fibrillation or premature ventricular contractions (PVCs). Patients with significant cardiac history should be optimized according the relevant guidelines before surgery is considered. * Normal cardiopulmonary function \[predicted forced expiratory volume in the first second(FEV1%) \>50% and ejection fraction (EF) \>50%of predicted value\]. Resting blood gas analysis showing arterial partial pressure of oxygen (PaO2)≥75 mmHg and arterial partial pressure of carbon dioxide (PaCO2) \<45 mmHg; Exclusion Criteria: * History of ipsilateral surgery and other conditions which can result in extensive pleural adhesion; * Coagulopathy, hypoxemia (PaO2 \<60 mmHg), hypercapnia \[arterial carbon dioxide tension(PaCO2) \>50 mmHg\]; * Significant cardiac history.

Outcomes

Primary Outcomes

Postoperative Pain

The postoperative pain is assessed using a Visual Analog Scale (VAS)

Time frame: From date of operation until the date of chest tube removal, assessed up to 7 days

Pain-associated inflammatory factor

the level of pain-associated inflammatory factor in blood, including CRP, PCT, IL6 and TNFa

Time frame: the first day after surgery

Dosage of analgesics