Studying the effects of Narrowband Ultraviolet B versus acitretin on psoriatic patients
Compare the effects of Narrowband Ultraviolet B versus acitretin on serum Omentin-1 level in psoriatic patients as case control study by dividing patients into 3 groups: group 1 include patients receive Narrowband Ultraviolet B, group II includes patients receive acitretin (0.5-1 mg/day) and control group. The duration of this study about 3 months after receving those interventions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
patients will exposed to sessions of NB-UVB phototherapy twice weekly for 3 months
patients will received acitretin in dose 0.5-1 mg/kg daily for 3 months
Faculty of medicine - Aswan university
Aswān, Egypt
Decrease Omentin-1 serum level in both groups treated with NB-UVB and Acitretin
This outcome indicates potential role of Omentin-1 in psoriasis pathogenesis and its involvement in pathogenesis of obesity and related diseases as metabolic syndrome. So it will be concluded that high levels of this protein could be marker against obesity and related disorders including psoriasis. Omentin-1 can be valuable marker for psoriasis severity detected by its correlation with psoriasis area severity index (PASI) score and for evaluating the therapeutic outcomes
Time frame: 3 months
Decrease PASI score in psoriatic patients
Decrease in PASI score in psoriatic patients after treatment with NB-UVB acitretin
Time frame: 3 months
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