Correlation Between SFRP1 and Colorectal Cancer and Adenoma

N/AUnknownNCT05204433

Xijing Hospital of Digestive Diseases220 enrolled

Overview

In summary, our study demonstrated the methylation sites of SFRP1 gene promoter in patients with colorectal cancer and adenoma and found SFRP1\_16\_17\_18 CpG site was good performance as a diagnostic marker of colorectal cancer.

Study Type

OBSERVATIONAL

Enrollment

220

Conditions

Early Diagnosis of Colorectal Cancer and Adenoma

Interventions

no interventionOTHER

no intervention

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * consecutive adult patients undergoing an outpatient endoscopy and histopathologically diagnosed as colorectal cancer or adenoma. Also, healthy individuals were invited to be enrolled. Exclusion Criteria: * Lynch syndrome * Familial adenomatous polyposis * MUTYH associated polyposis * Peutz-Jeghers syndrome * Juvenile polyposis syndrome * Serrated polyposis syndrome

Locations (1)

Jie Liang

Xi'an, Shaanxi, China

Outcomes

Primary Outcomes

effectiveness of methylation markers from stool samples

assess the effectiveness of methylation markers from stool samples in colon cancer patients, colorectal adenoma patients, compared with normal volunteers

Time frame: 3 years

Secondary Outcomes

assess the capacities of RF model in screening potential clinical biomarkers.

Time frame: 3 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.