The purpose of this study is to test whether treatment-resistant late life depression is associated with declines in memory and attention and brain structure and function.
The purpose of this study is to test whether treatment-resistant late life depression is associated with declines in memory and attention and brain structure and function. The study will also test if changes in brain structure and function are associated with decreases in memory. In this study, investigators will conduct a series of assessments/tests, mainly brain imaging and assessments of participant's memory and attention, to better understand how depression is linked to memory and thinking in older persons. Investigators hope that their study will help the scientific community to understand why some people with depressive symptoms that are resistant to treatment in late-life experience declines in their memory and attention and whether effective treatment of such depression reduces that risk. Finally, investigators hope that this study will eventually lead to the development of better treatment options.
Study Type
OBSERVATIONAL
Enrollment
506
Analyzing mechanisms of the LLD-dementia relationship through fMRI acquisitions and analyses, to capture the specific brain networks implicated in executive function and episodic memory decline.
Neuropsychological Data, including Montreal Cognitive Assessment (MoCA), Wide Range Achievement Test-4 (WRAT-4) Reading subtest, Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Delis-Kaplan Executive Function System (D-KEFS) (Color Word Interference, Trail Making and Verbal Fluency).
UCLA Late-Life Mood, Stress, and Wellness Research Program
Los Angeles, California, United States
Washington University School of Medicine Healthy Mind Lab
St Louis, Missouri, United States
Columbia University Adult and Late Life Depression Clinic
New York, New York, United States
UPMC Late-Life Depression, Evaluation, Prevention, and Treatment Program
Pittsburgh, Pennsylvania, United States
Persistent Depression Leading to Change in Cognition
To test whether persistent (non-remitting) depression has the ability to change cognition and lead to greater cognitive decline, and greater degradation of neural circuitry
Time frame: Baseline, 6-months, 24-months
Change in Neural Circuity
To test whether greater degradation of neural circuitry is associated with greater cognitive decline
Time frame: Baseline, 6-months, 24-months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Clinical scales, including the Everyday Cognition Scale (E-Cog), Global Clinical Dementia Rating (CDR), Performance Assessment of Selfcare Skills (PASS)--CIADL (Cognitive Instrumental Activities of Daily Living) Short version, Patient Health Questionnaire (PHQ-9), and Suicide Risk Assessments (Suicide Questions, Baseline Suicidal Ideation, Suicide Intent Scale, Beck Lethality Scale, Decision Outcome Inventory, Columbia-Suicide Severity Rating Scale, and High Suicide Risk Protocol).
Centre for Addiction and Mental Health
Toronto, Ontario, Canada