Safety and feasibility study investigating brain biopsy in severe head injury. When a patient undergoes craniotomy or ICP bolt insertion for trauma, a biopsy of brain tissue is taken. Blood, saliva, urine and faeces samples are also taken for 7 days following the brain biopsy. CSF is collected if a CSF drainage device is used.
A minor amendment was submitted to allow histological and immunohistochemical analysis of the samples.
Study Type
OBSERVATIONAL
Enrollment
25
Biopsy of brain tissue
Royal London Hospital
London, United Kingdom
Feasibility of brain biopsy
Is it feasible to perform brain biopsy through ICP bolt or at time of craniotomy in TBI in order to obtain diagnostic tissue?
Time frame: immediately after the intervention/procedure/surgery
Safety of brain biopsy
Is it safe to perform brain biopsy through ICP bolt or at time of craniotomy in TBI?
Time frame: immediately after the intervention/procedure/surgery
Classification of TBI
Classify TBI based on histopathological appearances
Time frame: immediately after the intervention/procedure/surgery
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