This study aims to determine the independent and combined effects of prebiotic fiber supplementation and exercise on the gut microbiome and human health.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
48
FOS (NUTRAFLORA® P-95, Ingredion) supplements (10g/day) will be consumed daily mixed with water.
During the intervention period, all participants will perform 6 weeks of supervised progressive multi-component exercise training consisting of moderate to vigorous aerobic and strength-based exercises (3x/wk.).
Maltodextrin (Globe 18DE Maltodextrin, Ingredion) supplements (10g/day) will be consumed daily mixed with water.
University of Illinois at Urbana-Champaign
Urbana, Illinois, United States
RECRUITINGChanges in gastrointestinal microbiota composition
Determine the impact of daily consumption of prebiotic combined with regular exercise on the gastrointestinal microbiota compared to control by sequencing the V4 region of the 16S rRNA gene in fecal samples.
Time frame: Baseline & 6-week mark
Changes in gastrointestinal microbial-derived metabolite concentrations
Determine the impact of daily consumption of prebiotic combined with regular exercise on the concentration of short-chain fatty acids compared to control.
Time frame: Baseline & 6-week mark
Changes in fasting glucose
Determine the impact of daily consumption of prebiotic combined with regular exercise on fasting glucose compared to control.
Time frame: Baseline & 6-week mark
Changes in fasting insulin
Determine the impact of daily consumption of prebiotic combined with regular exercise on fasting insulin compared to control.
Time frame: Baseline & 6-week mark
Changes in body composition
Determine the impact of daily consumption of prebiotic combined with regular exercise on body composition compared to control. This includes percentage of fat mass and lean mass.
Time frame: Baseline & 6-week mark
Changes in body fat distribution
Determine the impact of daily consumption of prebiotic combined with regular exercise on body fat distribution compared to control. This includes the weight of visceral fat and liver fat in kilograms.
Time frame: Baseline & 6-week mark
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Changes in cognition
Determine the impact of daily consumption of prebiotic combined with regular exercise on relational memory, hippocampal function, interference control, and selective attention compared to control. Outcomes will be assessed with computer tasks and participants will be equipped with an electrode cap.
Time frame: Baseline & 6-week mark